RCT supports kimchi-derived probiotics’ anti-obesity effects

RCT supports kimchi-derived probiotics’ anti-obesity effects

Twelve weeks of supplementation with Lactobacillus curvatus​ HY7601 and Lactobacillus plantarum​ KY1032 also led to improvements in waist circumference in a randomized, double-blind, placebo-controlled clinical trial with 72 overweight volunteers.

“HY7601 and KY1032 exerted anti‐obesity effects by regulating the gut microbiota composition, which could lead to effective therapeutic trials,” root scientists from Korean company hy Co in the journal Nutrients​.

“The findings demonstrate that HY7601 and KY1032 intake can alter the composition and diversity of the human gut microbiome, and thereby help prevent obesity and its associated metabolic syndrome.”

Gut microbiota and obesity

The link between the gut microbiota and obesity was first reported in 2006 by Jeffrey Gordon and his group at Washington University in St. Louis, who found that microbial populations in the gut are different between obese and lean people, and that when the obese people lost weight their microflora reverted back to that observed in a lean person. This suggested that obesity has a microbial component (Nature​, Vol. 444, pp. 1022-1023, 1027-1031​).

A 2013 paper in science​​(Vol. 341, Issue 6150), also led by Prof Gordon, found that transplanting gut bacteria from obese humans into germ-free mice leads to greater weight gain and fat accumulation than mice that were given bacteria from the guts of lean humans .

The findings showed that weight and fat gain is influenced by communities of microbes in the gut and their effect on the physical and metabolic traits of the host, leading to metabolic changes in the rodents that are associated with obesity in humans.

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